MOA of alpha glucosidase inhibitors:

Alpha-glucosidase inhibitors are a class of oral anti-diabetic drugs used for diabetes mellitus type 2

EXAMPLE: Acarbose 

MOA

(a) Reduces intestinal absorption of Starch, dextrin and disaccharide by inhibiting the action of alpha-glucosidase in intestinal brush border.

(b) Inhibition of the enzyme slows the absorption of carbohydrates. 

(c) Alpha glucosidase helps in the conversion of Oligosaccharides to monosaccharides which further absorbed and results in rise of postprandial rise in plasma glucose. 

(d) Inhibition of AG results in no conversion (or less) of Oligosaccharides to monosaccharides.

(e) As a result, postprandial rise in plasma glucose is reduced. 

Picture source: https://www.researchgate.net/figure/Mechanism-of-action-of-alpha-glucosidase-inhibitors_fig2_279991207

Side Effects:

  • GIT problems 
  • Liver Problems 
  • Hypoglycaemia 
  • Allergic Reactions 

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