Why Aspirin is Used in cardiovascular complications?

Aspirin is often used in the treatment and prevention of cardiovascular complications due to its blood-thinning properties. Low dose of Aspirin is used for the treatment of various CVS complications including MI and High blood Pressure. 

Mechanism of Action 

Aspirin irreversibly acetylate the serine part of both of the COX enzymes (COX-1, and COX-2). Low dose of Aspirin is used to irreversible blocking of TXA2. 

COXs are responsible for the conversion of AA to PGG2 to PGH2 and then Thromboxane A2 (TXA2) which upon binding to the TP (alpha and beta) receptor results in platelet aggregation. and induces blood clotting phenomenon. 

For example: Blood clotting in the atherosclerotic plaque results in the development of Angina (unstable).  

Inhibition of COXs Results decreased production of TXA2 and thus platelet aggregation does not occurs and Anginal condition may be prevented. thus decreased chances of developing Myocardial infraction.

ALSO, 

TXA2 is a potent vasoconstrictor in renal blood flow. 

TXA2 decreases the glomerular filtration and renal blood flow and decreasing the formation of urine and increases the Blood Pressure. 

Aspirin decreases the production of TXA2 in kidney and decreases the Blood Pressure. 


Conclusion: Aspirin is used as a blood thinning agent as well as it reduces the blood pressure that can prevent the rapture of blood vessels and can prevent the formation of Atherosclerosis thus diminishing the chance of various types of CVS complications. 

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