MOA of Paracetamol 

Paracetamol, also known as acetaminophen, is a widely used non-opioid analgesic and antipyretic agent. Despite its widespread use, the exact mechanism of action of paracetamol is not fully understood. However, it is generally believed to work in the following ways:

  1. Inhibition of Prostaglandin Synthesis: Paracetamol is thought to produce analgesia (pain relief) through a central inhibition of prostaglandin synthesis. Prostaglandins are produced by the body in response to injury and certain diseases. By reducing the production of prostaglandins in the brain and spinal cord, paracetamol can relieve pain.

  2. Inhibition of COX-1 and COX-2: Paracetamol inhibits the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are involved in the production of prostaglandins.

  3. Formation of N-arachidonoylphenolamine: In the brain and spinal cord, paracetamol can combine with arachidonic acid to form N-arachidonoylphenolamine.

It’s important to note that these mechanisms are still being studied and our understanding of how paracetamol works may evolve over time.


ADR



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